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CAS号 | 1130115-44-4 | 货号 | BCP34023 |
中文名 | Donafenib | ||
英文名 | Donafenib | ||
中文别名 | |||
英文别名 | Sorafenib (D3); CM-4307; CM 4307; CM4307;Bay 43-9006 (D3); | ||
SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F | ||
化学名称 | |||
分子式 | C21H13D3ClF3N4O3 | 分子量 | 467.85 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Donafenib is an orally available multikinase inhibitor that targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, donafenib binds to and blocks the activity of Raf kinase, and inhibits Raf-mediated signal transduction pathways. This inhibits cell proliferation in Raf-expressing tumor cells. In addition, this agent may inhibit unidentified RTKs, and thus may further block tumor cell proliferation in susceptible tumor cells. Raf, a serine/threonine protein kinase, plays a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Deregulation of this pathway often results in tumor cell proliferation and survival. |
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