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CEP-11981 结构式

CEP-11981

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货号 :BCP46664CAS号 :856691-93-5纯度:98%
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  • 基本信息与产品描述
CAS号 856691-93-5 货号 BCP46664
中文名 CEP-11981
英文名 CEP-11981
中文别名
英文别名 CEP11981; CEP 11981; BOL303213X; BOL-303213X; BOL 303213X; ESK981; ESK-981; ESK 981;
SMILES CC(C)CN1C2=C(C=C(C=C2)NC3=NC=CC=N3)C4=C1C5=C(C6=CN(N=C6CC5)C)C7=C4CNC7=O
化学名称
分子式 C28H27N7O 分子量 477.56
纯度 98% 配送 惯例下常温包邮
产品描述 CEP-11981 is a potent orally active inhibitor of multiple targets (TIE-2, VEGF-R1, 2, and 3, and FGF-R1), which having essential and nonredundant roles in tumor angiogenesis and vascular maintenance. CEP-11981 demonstrated significant preclinical cytostatic anti-tumor activity against human UC xenografts in a murine model, which was attributable to inhibition of angiogenesis. Clinical development of CEP-11981 in tolerable combination regimens and the discovery of tumor and host related biomarkers predictive for benefit are warranted. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death.
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