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CAS号 | 341031-54-7 | 货号 | BCP01768 |
关联产品 | 557795-19-4(苏尼替尼) | ||
中文名 | 苏尼替尼苹果酸盐 | ||
英文名 | Sunitinib Malate | ||
中文别名 | 苹果酸舒尼替尼; | ||
英文别名 | SU 11248 Malate;SU11248 Malate;SU-11248 Malate; | ||
SMILES | CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O | ||
化学名称 | |||
分子式 | C26H33FN4O7 | 分子量 | 532.56 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Sunitinib Malate is the orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. |
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