GSK 621659A
| CAS号 | 475489-15-7 | 货号 | BCP25985 |
| 中文名 | GSK 621659A | ||
| 英文名 | GSK 621659A | ||
| 中文别名 | |||
| 英文别名 | NVP-ADW742;ADW-742; | ||
| 分子式 | C28H31N5O | 分子量 | 453.58 |
| 生物活性 | GSK 552602A is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | IGF1R | ||
结构式
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