NVP-ADW742

  • 化学数据
CAS号 475488-23-4 货号 BCP27617
中文名 NVP-ADW742
英文名 NVP-ADW742
中文别名
英文别名 ADW; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A;
分子式 C28H31N5O 分子量 453.58
  • 用途
生物活性 NVP-ADW742, also known as ADW-742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 µmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti-tumor agent highly selective against IGF-IR. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells.
信号通路 Angiogenesis/Protein Tyrosine Kinase PI3K/Akt/mTOR Wnt/Stem Cell 
靶 点 IGF1R GSK3 

结构式

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