即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 1265966-31-1 | 货号 | BCP29576 |
中文名 | S49076 HCl | ||
英文名 | S49076 HCl | ||
中文别名 | |||
英文别名 | 1265965-19-2;S 49076 HCl;S-49076 HCl;S-49076 Hydrochloride;S49076 Hydrochloride;S 49076 Hydrochloride; | ||
SMILES | C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl | ||
化学名称 | |||
分子式 | C22H23ClN4O4S | 分子量 | 474.96 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth. |
Tags:S49076 HCl 供应商,S49076 HCl 购买,S49076 HCl 生产,S49076 HCl 批量,S49076 HCl 供应,S49076 HCl 订购,S49076 HCl 采购