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S49076 HCl 结构式

S49076 HCl

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP29576CAS号 :1265966-31-1纯度:98%
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  • 基本信息与产品描述
CAS号 1265966-31-1 货号 BCP29576
中文名 S49076 HCl
英文名 S49076 HCl
中文别名
英文别名 1265965-19-2;S 49076 HCl;S-49076 HCl;S-49076 Hydrochloride;S49076 Hydrochloride;S 49076 Hydrochloride;
SMILES C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl
化学名称
分子式 C22H23ClN4O4S 分子量 474.96
纯度 98% 配送 惯例下常温包邮
产品描述 S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 was established and correlated well with impact on tumor growth.
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