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ARQ 197 结构式

ARQ 197

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP28549CAS号 :1000873-98-2纯度:98%
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  • 基本信息与产品描述
CAS号 1000873-98-2 货号 BCP28549
中文名 ARQ 197
英文名 ARQ 197
中文别名
英文别名 Tivantinib;ARQ-197;ARQ197;
SMILES C1CC2=CC=CC3=C2N(C1)C=C3[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65
化学名称
分子式 C23H19N3O2 分子量 369.42
纯度 98% 配送 惯例下常温包邮
产品描述 ARQ-197 is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.
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