TAS-115

  • 化学数据
CAS号 1190836-34-0 货号 BCP34014
中文名 TAS-115
英文名 TAS-115
中文别名
英文别名 TAS 115, TAS115; Pamufetinib;
分子式 C27H23FN4O4S 分子量 518.56
  • 用途
生物活性 TAS-115 is a c-MET Inhibitor. TAS-115 inhibited the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. TAS-115 is extremely selective and specific, at least in vitro. In in vivo studies, TAS-115 completely suppressed the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. TAS-115 induced marked tumor shrinkage and prolonged survival in MET-amplified human cancer-bearing mice. TAS-115 is a unique VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Met VEGFR 

结构式

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