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SOMG-833 HCl 结构式

SOMG-833 HCl

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货号 :BCP49025CAS号 :1268264-10-3纯度:98%
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  • 基本信息与产品描述
CAS号 1268264-10-3 货号 BCP49025
中文名 SOMG-833 HCl
英文名 SOMG-833 HCl
中文别名
英文别名 SOMG 833 HCl; SOMG833 HCl; SOMG-833 Hydrochloride; SOMG833 Hydrochloride; SOMG 833 Hydrochloride; Zgwatinib Hydrochloride; Zgwatinib HCl;
SMILES CN1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC(=CC=C4)[N+](=O)[O-])C(F)(F)F)N=C2.Cl
化学名称
分子式 C22H23ClF3N5O2 分子量 481.9
纯度 98% 配送 惯例下常温包邮
产品描述 SOMG-833 HCl is a selective c-MET inhibitor that acts by blocking c-MET dependent neoplastic effects and exerting antitumor activity.SOMG-833 is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.
  • 技术资料和支持
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