即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 1268264-10-3 | 货号 | BCP49025 |
中文名 | SOMG-833 HCl | ||
英文名 | SOMG-833 HCl | ||
中文别名 | |||
英文别名 | SOMG 833 HCl; SOMG833 HCl; SOMG-833 Hydrochloride; SOMG833 Hydrochloride; SOMG 833 Hydrochloride; Zgwatinib Hydrochloride; Zgwatinib HCl; | ||
SMILES | CN1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC(=CC=C4)[N+](=O)[O-])C(F)(F)F)N=C2.Cl | ||
化学名称 | |||
分子式 | C22H23ClF3N5O2 | 分子量 | 481.9 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SOMG-833 HCl is a selective c-MET inhibitor that acts by blocking c-MET dependent neoplastic effects and exerting antitumor activity.SOMG-833 is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo. |
相关产品推荐
查看更多 >Tags:SOMG-833 HCl 供应商,SOMG-833 HCl 购买,SOMG-833 HCl 生产,SOMG-833 HCl 批量,SOMG-833 HCl 供应,SOMG-833 HCl 订购,SOMG-833 HCl 采购