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CAS号 | 1025720-94-8 | 货号 | BCP02303 |
关联产品 | 1196681-44-3 (BMS 777607) | ||
中文名 | BMS-777607 | ||
英文名 | BMS-777607 | ||
中文别名 | |||
英文别名 | 1196681-44-3;BMS817378; BMS 817378; BMS-817378; BMS777607;BMS 777607; ASLAN 002; ASLAN-002; ASLAN002; | ||
SMILES | O=C(NC1=CC=C(C(F)=C1)OC2=C(C(N)=NC=C2)Cl)C3=C(C=CN(C3=O)C4=CC=C(C=C4)F)OCC | ||
化学名称 | |||
分子式 | C25H19ClF2N4O4 | 分子量 | 512.89 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BMS-777607, also known as BMS-817378 and ASLAN-002, a Met tyrosine kinase inhibitor, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis. |
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