ARQ 197

  • 化学数据
CAS号 1000873-98-2 货号 BCP28549
中文名 ARQ 197
英文名 ARQ 197
中文别名
英文别名 Tivantinib;ARQ-197;ARQ197;
分子式 C23H19N3O2 分子量 369.42
  • 用途
生物活性 ARQ-197 is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Met 

结构式

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