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Motesanib Diphosphate 结构式

二磷酸莫替沙尼

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货号 :BCP01822CAS号 :857876-30-3纯度:98%
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  • 基本信息与产品描述
CAS号 857876-30-3 货号 BCP01822
中文名 二磷酸莫替沙尼
英文名 Motesanib Diphosphate
中文别名
英文别名 AMG-706;AMG 706;AMG706;
SMILES
化学名称
分子式 C22H23N5O.2H3PO4 分子量 569.44
纯度 98% 配送 惯例下常温包邮
产品描述 Motesanib Diphosphate has broad activity against the human VEGFR family, and displays >1000 selectivity against EGFR, Src, and p38 kinase. Motesanib Diphosphate significantly inhibits VEGF-induced cellular proliferation of HUVECs with an IC50 of 10 nM, while displaying little effect at bFGF-induced proliferation with an IC50 of >3,000 nM. Motesanib Diphosphate also potently inhibits PDGF-induced proliferation and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not effective against the EGF-induced EGFR phosphorylation and cell viability of A431 cells.Althouth displaying little antiproliferative activity on cell growth of HUVECs alone, Motesanib Diphosphate treatment significantly sensitizes the cells to fractionated radiation.
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