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SU14813 结构式

SU14813

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货号 :BCP27700CAS号 :627908-92-3纯度:98%
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  • 基本信息与产品描述
CAS号 627908-92-3 货号 BCP27700
中文名 SU14813
英文名 SU14813
中文别名
英文别名 SU-14813;SU 14813; SU014813; SU-014813; SU 014813;
SMILES
化学名称
分子式 C23H27FN4O4 分子量 442.48
纯度 98% 配送 惯例下常温包邮
产品描述 SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3) (1). SU14813 was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. SU14813 demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice.
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