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CAS号 | 1628606-05-2 | 货号 | BCP44095 |
中文名 | Vimseltinib | ||
英文名 | Vimseltinib | ||
中文别名 | |||
英文别名 | DCC-3014; DCC 3014; DCC3014; | ||
SMILES | CC1=C(C=CC(=N1)C2=CN=C(N(C2=O)C)NC(C)C)OC3=CC(=NC=C3)C4=CN(N=C4)C | ||
化学名称 | |||
分子式 | C23H25N7O2 | 分子量 | 431.49 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities. Upon administration, DCC-3014 targets and binds to CSF1R expressed on monocytes, macrophages, and osteoclasts and inhibits the binding of the CSF1R ligands colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34), to CSF1R. This prevents CSF1R activation and CSF1R-mediated signaling in these cells. This blocks the production of inflammatory mediators by macrophages and monocytes and reduces inflammation. |
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