培西达替尼盐酸盐 新
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规格 | 价格(CNY) | 是否现货 | 购买咨询 |
---|---|---|---|
10.00 mg | ¥500.00 | In-stock | 购买咨询 |
25.00 mg | ¥800.00 | In-stock | 购买咨询 |
100.00 mg | ¥2600.00 | In-stock | 购买咨询 |
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CAS号 | 2040295-03-0 | 货号 | BCP29551 |
中文名 | 培西达替尼盐酸盐 | ||
英文名 | Pexidartinib hydrochloride | ||
中文别名 | 吡昔替尼盐酸盐; | ||
英文别名 | PLX 3397 HCl;PLX-3397 HCl;Pexidartinib HCl;PLX3397 HCl;PLX-3397 hydrochloride; | ||
SMILES | C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F.Cl | ||
化学名称 | |||
分子式 | C20H16Cl2F3N5 | 分子量 | 454.278 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Pexidartinib Hydrochloride is the hydrochloride salt form of pexidartinib, a small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis. |
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