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Pexidartinib hydrochloride 结构式

培西达替尼盐酸盐

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP29551CAS号 :2040295-03-0纯度:98%
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  • 基本信息与产品描述
CAS号 2040295-03-0 货号 BCP29551
中文名 培西达替尼盐酸盐
英文名 Pexidartinib hydrochloride
中文别名 吡昔替尼盐酸盐;
英文别名 PLX 3397 HCl;PLX-3397 HCl;Pexidartinib HCl;PLX3397 HCl;PLX-3397 hydrochloride;
SMILES C1=CC(=NC=C1CC2=CNC3=NC=C(C=C23)Cl)NCC4=CN=C(C=C4)C(F)(F)F.Cl
化学名称
分子式 C20H16Cl2F3N5 分子量 454.278
纯度 98% 配送 惯例下常温包邮
产品描述 Pexidartinib Hydrochloride is the hydrochloride salt form of pexidartinib, a small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.
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