二磷酸莫替沙尼

  • 化学数据
CAS号 857876-30-3 货号 BCP01822
中文名 二磷酸莫替沙尼
英文名 Motesanib Diphosphate
中文别名
英文别名 AMG-706;AMG 706;AMG706;
分子式 C22H23N5O.2H3PO4 分子量 569.44
  • 用途
生物活性 Motesanib Diphosphate has broad activity against the human VEGFR family, and displays >1000 selectivity against EGFR, Src, and p38 kinase. Motesanib Diphosphate significantly inhibits VEGF-induced cellular proliferation of HUVECs with an IC50 of 10 nM, while displaying little effect at bFGF-induced proliferation with an IC50 of >3,000 nM. Motesanib Diphosphate also potently inhibits PDGF-induced proliferation and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not effective against the EGF-induced EGFR phosphorylation and cell viability of A431 cells.Althouth displaying little antiproliferative activity on cell growth of HUVECs alone, Motesanib Diphosphate treatment significantly sensitizes the cells to fractionated radiation.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 PDGFR VEGFR c Kit 

结构式

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