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Pazopanib 结构式

帕唑帕尼

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货号 :BCP01839CAS号 :444731-52-6纯度:98%
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  • 基本信息与产品描述
CAS号 444731-52-6 货号 BCP01839
关联产品 635702-64-6(盐酸帕唑帕尼)
中文名 帕唑帕尼
英文名 Pazopanib
中文别名
英文别名 GW 786034;GW-786034;GW786034;
SMILES
化学名称
分子式 C21H23N7O2S 分子量 437.53
纯度 98% 配送 惯例下常温包邮
产品描述 Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.
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