即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 444731-52-6 | 货号 | BCP01839 |
关联产品 | 635702-64-6(盐酸帕唑帕尼) | ||
中文名 | 帕唑帕尼 | ||
英文名 | Pazopanib | ||
中文别名 | |||
英文别名 | GW 786034;GW-786034;GW786034; | ||
SMILES | |||
化学名称 | |||
分子式 | C21H23N7O2S | 分子量 | 437.53 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability. |
Tags:Pazopanib 供应商,Pazopanib 购买,Pazopanib 生产,Pazopanib 批量,Pazopanib 供应,Pazopanib 订购,Pazopanib 采购