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Rosiptor acetate 结构式

Rosiptor acetate

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货号 :BCP24919CAS号 :782487-29-0纯度:98%
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  • 基本信息与产品描述
CAS号 782487-29-0 货号 BCP24919
关联产品 782487-28-9(Rosiptor)
中文名 Rosiptor acetate
英文名 Rosiptor acetate
中文别名
英文别名 AQX-1125 acetate;AQX1125 acetate;AQX 1125 acetate;
SMILES CC(=O)O.CC1(CCC(CC1CO)O)C2CCC3(C(C2CN)CCC3=C)C
化学名称
分子式 C22H39NO4 分子量 381.56
纯度 98% 配送 惯例下常温包邮
产品描述 Rosiptor, also known as AQX-​1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases.
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