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CAS号 | 782487-29-0 | 货号 | BCP24919 |
关联产品 | 782487-28-9(Rosiptor) | ||
中文名 | Rosiptor acetate | ||
英文名 | Rosiptor acetate | ||
中文别名 | |||
英文别名 | AQX-1125 acetate;AQX1125 acetate;AQX 1125 acetate; | ||
SMILES | CC(=O)O.CC1(CCC(CC1CO)O)C2CCC3(C(C2CN)CCC3=C)C | ||
化学名称 | |||
分子式 | C22H39NO4 | 分子量 | 381.56 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Rosiptor, also known as AQX-1125 is a potent and selective SHIP1 activator currently in clinical development. AQX-1125 inhibited Akt phosphorylation in SHIP1-proficient but not in SHIP1-deficient cells, reduced cytokine production in splenocytes, inhibited the activation of mast cells and inhibited human leukocyte chemotaxis. AQX-1125 suppresses leukocyte accumulation and inflammatory mediator release in rodent models of pulmonary inflammation and allergy. As shown in the mouse model of LPS-induced lung inflammation, the efficacy of the compound is dependent on the presence of SHIP1. Pharmacological SHIP1 activation may have clinical potential for the treatment of pulmonary inflammatory diseases. |
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