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CAS号 | 39674-97-0 | 货号 | BCP45529 |
中文名 | BVT948 | ||
英文名 | BVT948 | ||
中文别名 | |||
英文别名 | BVT-948; BVT 948; SPS8I3; SPS-8I3; SPS 8I3; | ||
SMILES | CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C | ||
化学名称 | |||
分子式 | C14H11NO3 | 分子量 | 241.24 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BVT948 is a protein tyrosine phosphatases (PTP) inhibitor (IC50 = 0.09 - 1.7 μM). BVT948 inhibits NF-κB activation by suppressing IκBα degradation and the nuclear translocation of NF-κB in TPA-treated MCF-7 cells. BVT948 didn’t block TPA-induced AP-1 activation in MCF-7 cells. BVT948 blocks MMP-9 expression of breast cancer cells by inhibiting the TPA-stimulated NF-κB pathway. |
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