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CAS号 | 1008510-37-9 | 货号 | BCP46999 |
关联产品 | 1809275-69-1(Razuprotafib sodium) | ||
中文名 | 雷罗他非 | ||
英文名 | Razuprotafib | ||
中文别名 | |||
英文别名 | AKB-9778; AKB 9778; AKB9778; | ||
SMILES | COC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4 | ||
化学名称 | |||
分子式 | C26H26N4O6S3 | 分子量 | 586.7 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Razuprotafib is a small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), with potential vasculature stabilizing activity. Upon administration, razuprotafib targets, binds to and inhibits VE-PTP, which is a negative regulator of the endothelial cell (EC)-specific receptor tyrosine kinase (RTK) Tie2. This restores Tie2 activation, which may improve endothelial function and stabilize blood vessels. VE-PTP is upregulated in stressed endothelium associated with a variety of diseases. Tie2 plays an important role in endothelial function and vascular stability. A decrease in Tie2 activation leads to vascular leakage and inflammation. |
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