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Razuprotafib 结构式

雷罗他非

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP46999CAS号 :1008510-37-9纯度:98%
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  • 基本信息与产品描述
CAS号 1008510-37-9 货号 BCP46999
关联产品 1809275-69-1(Razuprotafib sodium)
中文名 雷罗他非
英文名 Razuprotafib
中文别名
英文别名 AKB-9778; AKB 9778; AKB9778;
SMILES COC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)NS(=O)(=O)O)C3=CSC(=N3)C4=CC=CS4
化学名称
分子式 C26H26N4O6S3 分子量 586.7
纯度 98% 配送 惯例下常温包邮
产品描述 Razuprotafib is a small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), with potential vasculature stabilizing activity. Upon administration, razuprotafib targets, binds to and inhibits VE-PTP, which is a negative regulator of the endothelial cell (EC)-specific receptor tyrosine kinase (RTK) Tie2. This restores Tie2 activation, which may improve endothelial function and stabilize blood vessels. VE-PTP is upregulated in stressed endothelium associated with a variety of diseases. Tie2 plays an important role in endothelial function and vascular stability. A decrease in Tie2 activation leads to vascular leakage and inflammation.
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