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CAS号 | 1451272-71-1 | 货号 | BCP45955 |
中文名 | SBI-425 | ||
英文名 | SBI-425 | ||
中文别名 | |||
英文别名 | SBI425;SBI 425; | ||
SMILES | COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N | ||
化学名称 | |||
分子式 | C13H12ClN3O4S | 分子量 | 341.77 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | SBI-425 is a potent, selective and oral bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with an IC50 value of 0.016 μM. SBI-425 robustly inhibits TNAP in vivo after oral dosing. Furthermore, SBI-425 demonstrated activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE. |
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