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CAS号 | 2242616-04-0 | 货号 | BCP48942 |
关联产品 | 2022961-17-5(Raphin1) | ||
中文名 | Raphin1 acetate | ||
英文名 | Raphin1 acetate | ||
中文别名 | |||
英文别名 | |||
SMILES | CC(=O)O.C1=CC(=C(C(=C1)Cl)Cl)C=NN=C(N)N | ||
化学名称 | |||
分子式 | C10H12Cl2N4O2 | 分子量 | 291.13 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease. |
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