Galunisertib 新促

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02173CAS号：700874-72-2纯度：98%

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CAS号	700874-72-2	货号	BCP02173
中文名	Galunisertib
英文名	Galunisertib
中文别名
英文别名	LY2157299; LY-2157299; LY 2157299;
SMILES	CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N
化学名称
分子式	C22H19N5O	分子量	369.42
纯度	98%	配送	惯例下常温包邮
产品描述	LY2157299 potently inhibits the TGFβ receptor signaling. LY2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. LY2157299 also shows dose dependent potentiation of VEGF or bFGF induced cell proliferation in HUVEC. LY2157299 also promotes VEGF induced HUVEC cell migration. LY2157299 potentiates angiogenesis in the in vitro VEGF-stimulated cord formation assay. LY2157299 inhibits TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner. LY2157199 treatment stimulates hematopoiesis from primary MDS bone marrow specimens.In human glioblastoma (GBM) cells, LY2157299 treatment blocks signaling through the heteromeric TGFβ receptor complex to reduce levels of active, phosphorylated SMAD.

Galunisertib 新 促