Galunisertib
| CAS号 | 700874-72-2 | 货号 | BCP02173 |
| 中文名 | Galunisertib | ||
| 英文名 | Galunisertib | ||
| 中文别名 | |||
| 英文别名 | LY2157299; LY-2157299; LY 2157299; | ||
| 分子式 | C22H19N5O | 分子量 | 369.42 |
| 生物活性 | LY2157299 potently inhibits the TGFβ receptor signaling. LY2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. LY2157299 also shows dose dependent potentiation of VEGF or bFGF induced cell proliferation in HUVEC. LY2157299 also promotes VEGF induced HUVEC cell migration. LY2157299 potentiates angiogenesis in the in vitro VEGF-stimulated cord formation assay. LY2157299 inhibits TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner. LY2157199 treatment stimulates hematopoiesis from primary MDS bone marrow specimens.In human glioblastoma (GBM) cells, LY2157299 treatment blocks signaling through the heteromeric TGFβ receptor complex to reduce levels of active, phosphorylated SMAD. | ||
| 信号通路 | TGF beta/Smad Wnt/Stem Cell | ||
| 靶 点 | BMP/TGF beta Receptor TGF β/Smad | ||
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Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury
购于瀚香生物(Biochempartner)的Galunisertib(CAS:700874-72-2)被引用 |
|
Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells
购于瀚香生物(Biochempartner)的Galunisertib(CAS:700874-72-2)被引用 |
结构式
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