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CAS号 | 1409968-46-2 | 货号 | BCP29917 |
中文名 | (+)-ITD-1 | ||
英文名 | (+)-ITD-1 | ||
中文别名 | |||
英文别名 | ITD-1, (+)-; | ||
SMILES | CCOC(=O)C1=C(NC2=C(C1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C2)(C)C)C | ||
化学名称 | |||
分子式 | C27H29NO3 | 分子量 | 415.52 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | (+)-ITD-1 is the (+)-enantiomer of ITD 1 that is more active. ITD-1 is a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (−)-ITD 1, respectively for TGF-β inhibition) that clears the type II TGFβ receptor from the cell surface. ITD 1 promotes the differentiation of cardiomyocytes and cardiogenesis in murine embryonic stem cell (mESCs). |
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