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Kartogenin 结构式

Kartogenin

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货号 :BCP09135CAS号 :4727-31-5纯度:98%
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  • 基本信息与产品描述
CAS号 4727-31-5 货号 BCP09135
中文名 Kartogenin
英文名 Kartogenin
中文别名
英文别名 KGN; 2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid; 2-[(4-phenylphenyl)carbamoyl]benzoic acid;4'-Phenylphthalanilic Acid;
SMILES
化学名称
分子式 C20H15NO3 分子量 317.34
纯度 98% 配送 惯例下常温包邮
产品描述 Kartogenin is a small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program . KGN stimulated type-I collagen synthesis of fibroblasts at the mRNA and protein levels in a time-dependent manner, but KGN did not induce expression of α-skeletal muscle actin (α-sma) or matrix metallopeptidase1 (MMP1), MMP9 in vitro . KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4/smad5 pathway.
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