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Halofuginone hydrobromide 结构式

常山酮氢溴酸盐

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货号 :BCP24882CAS号 :17395-31-2纯度:98%
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  • 基本信息与产品描述
CAS号 17395-31-2 货号 BCP24882
中文名 常山酮氢溴酸盐
英文名 Halofuginone hydrobromide
中文别名
英文别名 RU-19110 hydrobromide;
SMILES C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
化学名称
分子式 C16H18Br2ClN3O3 分子量 495.59
纯度 98% 配送 惯例下常温包邮
产品描述 Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
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