Crenolanib besylate

  • 化学数据
CAS号 670220-93-6 货号 BCP24113
中文名 Crenolanib besylate
英文名 Crenolanib besylate
中文别名
英文别名 Crenolanib besilate; CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002;
分子式 C32H35N5O5S 分子量 601.72
  • 用途
生物活性 Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 PDGFR 

结构式

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