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IC 261 结构式

IC 261

参考资料 仅供科学研究，不可用于个人用途。
货号 ：BCP16652CAS号 ：186611-52-9纯度：98%
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  • 基本信息与产品描述
CAS号 186611-52-9 货号 BCP16652
中文名 IC 261
英文名 IC 261
中文别名
英文别名 IC-261;IC261;SU5607; SU-5607; SU 5607; SU 5607;
SMILES O=C1NC2=C(C=CC=C2)/C1=CC3=C(OC)C=C(OC)C=C3OC
化学名称
分子式 C18H17NO4 分子量 311.33
纯度 98% 配送 惯例下常温包邮
产品描述 SU5607, also known as IC-261, is a potent and selective CK1 inhibitor. IC261 triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. IC261 binds to tubulin with an affinity similar to colchicine and is a potent inhibitor of microtubule polymerization. This activity accounts for many of the diverse biological effects of IC261 and, most importantly, for its selective cancer cell killing.
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