IC 261
  • 化学数据
CAS号 186611-52-9 货号 BCP16652
中文名 IC 261
英文名 IC 261
中文别名
英文别名 IC-261;IC261;SU5607; SU-5607; SU 5607; SU 5607;
分子式 C18H17NO4 分子量 311.33
  • 用途
生物活性 SU5607, also known as IC-261, is a potent and selective CK1 inhibitor. IC261 triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. IC261 binds to tubulin with an affinity similar to colchicine and is a potent inhibitor of microtubule polymerization. This activity accounts for many of the diverse biological effects of IC261 and, most importantly, for its selective cancer cell killing.
信号通路 Cell Cycle/DNA Damage Wnt/Stem Cell 
靶 点 Casein Kinase 

结构式

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