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CAS号 | 301836-43-1 | 货号 | BCP09776 |
中文名 | D4476 | ||
英文名 | D4476 | ||
中文别名 | |||
英文别名 | Casein Kinase I Inhibitor;D 4476;D-4476; | ||
SMILES | |||
化学名称 | |||
分子式 | C23H18N4O3 | 分子量 | 398.41 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | D4476 is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested, including Akt1 (PKB), SGK and GSK-3b. D4476 may either inhibit or foster apoptosis. D4476 inhibits nuclear export of eIF6 and results in nuclear accumulation of eIF6. In HeLa cells D4476 has been used to inhibit CK-1 phosphorylation of RhoB but not RhoA or RhoC activating RhoB dependent actin fiber formation. D4476 has been observed to block the Wnt-3a-induced phosphorylation and shift in electrophoretic migration of Dvl-1(dishevelled, Dvl). |
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