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CAS号 | 1293395-67-1 | 货号 | BCP29752 |
中文名 | PF-5006739 | ||
英文名 | PF-5006739 | ||
中文别名 | |||
英文别名 | PF 5006739; PF5006739; | ||
SMILES | C1CN(CCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F)CC5=NOC=C5 | ||
化学名称 | |||
分子式 | C22H22FN7O | 分子量 | 419.45 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PF-5006739 is a Potent CK1δ/ε inhibitor. PF-5006739 attenuates opioid drug-seeking behavior. PF-5006739 possesses a desirable profile, with low nanomolar in vitro potency for CK1δ/ε (IC50 = 3.9 and 17.0 nM, respectively) and high kinome selectivity. In vivo, PF-5006739 demonstrated robust centrally mediated circadian rhythm phase-delaying effects in both nocturnal and diurnal animal models. Further, PF-5006739 dose-dependently attenuated opioid drug-seeking behavior in a rodent operant reinstatement model in animals trained to self-administer fentanyl. |
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