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CAS号 | 950912-80-8 | 货号 | BCP04305 |
中文名 | PF670462 | ||
英文名 | PF670462 | ||
中文别名 | |||
英文别名 | PF 670462;PF-670462; | ||
SMILES | |||
化学名称 | |||
分子式 | C19H20FN5.2HCl | 分子量 | 410.32 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PF-670462 has been proved to be both a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations; in transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo. |
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