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PF670462 结构式

PF670462

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货号 :BCP04305CAS号 :950912-80-8纯度:98%
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  • 基本信息与产品描述
CAS号 950912-80-8 货号 BCP04305
中文名 PF670462
英文名 PF670462
中文别名
英文别名 PF 670462;PF-670462;
SMILES
化学名称
分子式 C19H20FN5.2HCl 分子量 410.32
纯度 98% 配送 惯例下常温包邮
产品描述 PF-670462 has been proved to be both a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations; in transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo.
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