Vimseltinib

  • 化学数据
CAS号 1628606-05-2 货号 BCP44095
中文名 Vimseltinib
英文名 Vimseltinib
中文别名
英文别名 DCC-3014; DCC 3014; DCC3014;
分子式 C23H25N7O2 分子量 431.49
  • 用途
生物活性 Vimseltinib, also known as DCC-3014, is a potent and orally active inhibitor of the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; C-FMS; CD115; M-CSFR), with potential antineoplastic, macrophage checkpoint-inhibitory and immunomodulating activities. Upon administration, DCC-3014 targets and binds to CSF1R expressed on monocytes, macrophages, and osteoclasts and inhibits the binding of the CSF1R ligands colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34), to CSF1R. This prevents CSF1R activation and CSF1R-mediated signaling in these cells. This blocks the production of inflammatory mediators by macrophages and monocytes and reduces inflammation.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Kit cFMS 

结构式

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