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CAS号 | 953769-46-5 | 货号 | BCP14029 |
中文名 | BLZ945 | ||
英文名 | BLZ945 | ||
中文别名 | 索图替尼; | ||
英文别名 | BLZ 945; BLZ-945;Sotuletinib; | ||
SMILES | O=C(C1=NC=CC(OC2=CC=C3N=C(N[C@]4[C@](O)CCCC4)SC3=C2)=C1)NC | ||
化学名称 | |||
分子式 | C20H22N4O3S | 分子量 | 398.48 |
纯度 | 95% | 配送 | 惯例下常温包邮 |
产品描述 | BLZ945 is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis. |
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