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GW2580 结构式

GW2580

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货号 :BCP06918CAS号 :870483-87-7纯度:98%
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  • 基本信息与产品描述
CAS号 870483-87-7 货号 BCP06918
中文名 GW2580
英文名 GW2580
中文别名
英文别名 GW 2580;GW-2580;
SMILES
化学名称
分子式 C20H22N4O3 分子量 366.41
纯度 98% 配送 惯例下常温包邮
产品描述 GW2580 completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 inhibits the growth of CSF-1 stimulated M-NFS-60 myeloid tumor cells, serum stimulated NSO myeloid tumor cells, CSF-1 stimulated freshly isolated human monocytes, and VEGF stimulated human umbilical vein vascular endothelial cells with IC50 of 0.33, 13.5, 0.47 and 12 μM, respectively. 1 μM GW2580 completely inhibits CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes and completely inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone. GW2580 inhibits CSF1R phosphorylation in RAW264.7 murine macrophages stimulated with 10 ng/mL with IC50 of approximately 10 nM. GW2580 also inhibits TRKA activity with IC50 of 0.88 μM.
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