JNJ-28312141 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP28018CAS号：885692-52-4纯度：98%

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CAS号	885692-52-4	货号	BCP28018
中文名	JNJ-28312141
英文名	JNJ-28312141
中文别名
英文别名	JNJ28312141; JNJ 28312141;
SMILES	CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4
化学名称
分子式	C26H32N6O2	分子量	460.58
纯度	98%	配送	惯例下常温包邮
产品描述	JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM; shows narrow kinase selectivity profile, also potently inhibits KIT (IC50=5 nM), AXL (12 nM), TRKA (15 nM), FLT3 (30 nM), and LCK (88 nM); inhibits CSF-1-induced CSF-1R phosphorylation with IC50 of 5 nM, inhibits CSF-1-dependent proliferation of mouse macrophages and CSF-1-induced expression of MCP-1 by human monocytes with IC50 of 3 nM; inhibits the ITD-FLT3-dependent proliferation of MV-4-11 cells with IC50 of 21 nM, inhibits FLT3 ligand-induced FLT3 phosphorylation in recombinant Baf3 cells with IC50 of 76 nM; demonstrates potential therapeutic activity in AML, solid tumors and bone metastases in vivo.