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CAS号 | 290815-26-8 | 货号 | BCP28417 |
中文名 | 阿伏生坦 | ||
英文名 | Avosentan | ||
中文别名 | |||
英文别名 | SPP301; SPP301; SPP301; RO 67-0565; RO-67-0565; RO67-0565; R-639; | ||
SMILES | CC1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC=NC=C3)OC)OC4=CC=CC=C4OC | ||
化学名称 | |||
分子式 | C23H21N5O5S | 分子量 | 479.5 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Avosentan is an endothelin receptor antagonist. Avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. Avosentan reduces albuminuria when added to standard treatment in people with type 2 diabetes and overt nephropathy but induces significant fluid overload and congestive heart failure. |
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