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CAS号 | 147536-97-8 | 货号 | BCP05202 |
中文名 | 伯森坦 | ||
英文名 | Bosentan | ||
中文别名 | 波生坦; | ||
英文别名 | |||
SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC | ||
化学名称 | |||
分子式 | C27H29N5O6S | 分子量 | 551.61 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. |
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