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CAS号 | 1103522-45-7 | 货号 | BCP28125 |
中文名 | 阿普昔腾坦 | ||
英文名 | Aprocitentan | ||
中文别名 | 阿普洛腾坦;N-去甲基马西替坦; | ||
英文别名 | N-Despropyl-macitentan;ACT-132577; ACT 132577; ACT132577; | ||
SMILES | O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O | ||
化学名称 | |||
分子式 | C16H14Br2N6O4S | 分子量 | 546.19 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Aprocitentan, also known as ACT-132577, is an endothelin receptor antagonist and an pharmacologically active metabolite of macitentan (MedKoo Cat#205912). Aprocitentan antagonized the specific binding of ET-1 on membranes of cells overexpressing ET(A) and ET(B) receptors and blunted ET-1-induced calcium mobilization in various natural cell lines, with inhibitory constants within the nanomolar range. |
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