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Milademetan tosylate monohydrate 结构式

Milademetan tosylate monohydrate

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货号 :BCP31919CAS号 :2095625-97-9纯度:98%
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  • 基本信息与产品描述
CAS号 2095625-97-9 货号 BCP31919
中文名 Milademetan tosylate monohydrate
英文名 Milademetan tosylate monohydrate
中文别名
英文别名 DS3032b; DS-3032b; DS 3032b; DS3032; DS-3032; DS 3032;
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CC1(CCC2(CC1)C3(C(C(N2)C(=O)NC4CCC(OC4)C(=O)N)C5=C(C(=NC=C5)Cl)F)C6=C(C=C(C=C6)Cl)NC3=O)C.O
化学名称
分子式 C37H44Cl2FN5O8S 分子量 808.74
纯度 98% 配送 惯例下常温包邮
产品描述 Milademetan, also known as DS-3032b, is a potent and selective MDM2 inhibitor with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
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