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Alrizomadlin

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货号 :BCP25148CAS号 :1818393-16-6纯度:98%
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  • 基本信息与产品描述
CAS号 1818393-16-6 货号 BCP25148
中文名 Alrizomadlin
英文名 Alrizomadlin
中文别名
英文别名 AA 115; AA115; APG 115; APG115; APG-115;AA-115;
SMILES CCN1C(C(C2(C13CCCCC3)C4=C(C=C(C=C4)Cl)NC2=O)C5=C(C(=CC=C5)Cl)F)C(=O)NC67CCC(CC6)(CC7)C(=O)O
化学名称
分子式 C34H38Cl2FN3O4 分子量 642.59
纯度 98% 配送 惯例下常温包邮
产品描述 Alrizomadlin is an orally available inhibitor of human homolog of double minute 2 (HDM2; mouse double minute 2 homolog; MDM2), with potential antineoplastic activity. Upon oral administration,alrizomadlin binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival.
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