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HDM201 结构式

HDM-201

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货号 :BCP20814CAS号 :1448867-41-1纯度:98%
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  • 基本信息与产品描述
CAS号 1448867-41-1 货号 BCP20814
中文名 HDM-201
英文名 HDM201
中文别名
英文别名 Siremadlin; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;
SMILES
化学名称
分子式 C26H24Cl2N6O4 分子量 555.42
纯度 98% 配送 惯例下常温包邮
产品描述 HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. HDM2 inhibitor HDM201 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
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