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CAS号 | 1448867-41-1 | 货号 | BCP20814 |
中文名 | HDM-201 | ||
英文名 | HDM201 | ||
中文别名 | |||
英文别名 | Siremadlin; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201; | ||
SMILES | |||
化学名称 | |||
分子式 | C26H24Cl2N6O4 | 分子量 | 555.42 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. HDM2 inhibitor HDM201 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). |
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