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Nutlin-3b 结构式

Nutlin-3b

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货号 :BCP05162CAS号 :675576-97-3纯度:98%
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  • 基本信息与产品描述
CAS号 675576-97-3 货号 BCP05162
中文名 Nutlin-3b
英文名 Nutlin-3b
中文别名
英文别名 Nutlin 3b;Nutlin3b;
SMILES
化学名称
分子式 C30H30Cl2N4O4 分子量 581.49
纯度 98% 配送 惯例下常温包邮
产品描述 Nutlin-3b is useful as a negative control s for non-MDM2-related cellular activities. Nutlin-3a induces the expression of MDM2 and p21 (but not p53) only in cells with wild-type p53. Nutlin-3b has no effect regardless of the p53 status of the cells. Only the active enantiomer Nutlin-3a shows a potent antiproliferative activity and clear separation of potency between the cells harboring wild-type p53 and those harboring mutant p53. The potency of Nutlin-3b is much lower in the wild-type p53 cells and nearly identical to the potency of Nutlin-3a against the mutant p53 cells. After 48 hours of exposure to the Nutlin-3a, 45% of the cell population became TUNEL positive, but cells treated with the Nutlin-3b are indistinguishable from the untreated controls.
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