即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 924759-42-2 | 货号 | BCP48539 |
中文名 | BT44 | ||
英文名 | BT44 | ||
中文别名 | |||
英文别名 | BT-44; BT 44; | ||
SMILES | O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=CC=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F | ||
化学名称 | |||
分子式 | C28H27F4N3O4S | 分子量 | 577.59 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. |
相关产品推荐
查看更多 >Tags:BT44 供应商,BT44 购买,BT44 生产,BT44 批量,BT44 供应,BT44 订购,BT44 采购