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CAS号 | 882405-89-2 | 货号 | BCP24855 |
中文名 | BBT594 | ||
英文名 | BBT594 | ||
中文别名 | |||
英文别名 | BBT-594; BBT 594; NVP-BBT594; NVP BBT594; NVP BBT-594; | ||
SMILES | CC(=O)NC1=CC(=NC=N1)OC2=CC3=C(C=C2)N(CC3)C(=O)NC4=CC(=C(C=C4)CN5CCN(CC5)C)C(F)(F)F | ||
化学名称 | |||
分子式 | C28H30F3N7O3 | 分子量 | 569.58 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BBT594, also known as NVP-BBT594, is potent and selective RET and JAK2 inhibitor. NVP-BBT594 impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells. NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment. GDNF-RET signaling as a rational therapeutic target may be useful to combat or delay the onset of AI resistance in breast cancer. |
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