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RET Kinase inhibitor 1  结构式

RET Kinase inhibitor 1

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP23560CAS号 :1627856-64-7纯度:98%
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  • 基本信息与产品描述
CAS号 1627856-64-7 货号 BCP23560
中文名 RET Kinase inhibitor 1
英文名 RET Kinase inhibitor 1 
中文别名
英文别名 GSK3179106; GSK-3179106; GSK 3179106;
SMILES
化学名称
分子式 C22H21F4N3O4 分子量 467.41
纯度 98% 配送 惯例下常温包邮
产品描述 GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo. GSK3179106 is being developed by GlaxoSmithKline for the treatment of irritable bowel syndrome. GSK3179106 showed IC50s of 0.4 and 11 nM in the biochemical assay and cellular assay, respectively. GSK3179106 had a clean genotoxic profile with no embedded genotoxicity liabilities.
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