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CAS号 | 2097132-93-7 | 货号 | BCP31224 |
中文名 | cis-Pralsetinib | ||
英文名 | cis-Pralsetinib | ||
中文别名 | |||
英文别名 | cis-Blu667;cis-Blu 667;cis-Blu-667;BLU-667 trans form; | ||
SMILES | CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC | ||
化学名称 | |||
分子式 | C27H32FN9O2 | 分子量 | 533.6 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | cis-Pralsetinib is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50 values ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types. |
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