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CAS号 | 269730-03-2 | 货号 | BCP08977 |
中文名 | RPI-1 | ||
英文名 | RPI-1 | ||
中文别名 | |||
英文别名 | RPI1;RPI 1; | ||
SMILES | |||
化学名称 | |||
分子式 | C17H15NO4 | 分子量 | 297.31 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. Recently it was discover that the compound also inhibits c-Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus not surprisingly RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size (IC50 = 24.5 + 0.5 microM). Compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity. It appears that " Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes ?-catenin transcriptional activity to drive thyrocyte neoplastic transformation". It appears that we do not have anything specific in Ret area. Handbook lists RPI-1 as Ret inhibitor. |
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