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RPI-1

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货号 :BCP08977CAS号 :269730-03-2纯度:98%
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  • 基本信息与产品描述
CAS号 269730-03-2 货号 BCP08977
中文名 RPI-1
英文名 RPI-1
中文别名
英文别名 RPI1;RPI 1;
SMILES
化学名称
分子式 C17H15NO4 分子量 297.31
纯度 98% 配送 惯例下常温包邮
产品描述 RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. Recently it was discover that the compound also inhibits c-Met. Increased tumorigenicity, motility, and invasiveness have been described as biological consequences of HGF/Met deregulation in tumor cells, thus not surprisingly RPI-1 treatment of H460 cells resulted in a strong reduction of both colony number and size (IC50 = 24.5 + 0.5 microM). Compound is also active at mouse NSCLC H460 xenograft tumor and metastasis model. Mechanistically RPI-1 inhibits Met phosphorylation at Tyr1234/Tyr1235, known to activate the intrinsic kinase activity. It appears that " Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes ?-catenin transcriptional activity to drive thyrocyte neoplastic transformation". It appears that we do not have anything specific in Ret area. Handbook lists RPI-1 as Ret inhibitor.
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