BT44
| CAS号 | 924759-42-2 | 货号 | BCP48539 |
| 中文名 | BT44 | ||
| 英文名 | BT44 | ||
| 中文别名 | |||
| 英文别名 | BT-44; BT 44; | ||
| 分子式 | C28H27F4N3O4S | 分子量 | 577.59 |
| 生物活性 | RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | RET | ||
结构式
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